This program supports research career development for pediatricians who are commencing basic science research relevant to the field of pediatrics. Please note that projects proposing patient-oriented research are not eligible for this opportunity.

Examples of responsive projects are listed below. This list is not meant to be inclusive, but rather provides some general examples of the types of scope that are appropriate for this program.

• Laboratory-based projects to understand the basic mechanisms of diseases affecting children
• Basic investigation into novel therapies or diagnostics at the bench or in animal models
• Laboratory-based investigation into genetic and epigenetic origins of childhood diseases

Projects in the following areas are not responsive to this particular funding opportunity:

• Clinical trials of any kind, including those performing laboratory assays from patient samples
• Descriptive projects linked to human specimens that lack a basic, mechanistic focus
• Outcomes research or epidemiologic studies

At the time of award, Atlanta Pediatric Scholars must:

• Devote a minimum effort of 9 person-months (75% effort) to research during the appointment of the K12 award.
• Be a citizen or a non-citizen national of the United States or have been lawfully admitted for permanent residence.
• Be a pediatrician holding an MD or DO degree.
• Have completed postgraduate residency training in pediatrics; completion of subspecialty training is not required as scholars may be considered for appointment to the K12 program in the final research year of subspecialty fellowship training, provided the fellowship provides basic science training within the scope of this K12 program.
• Be no more than 4 years after attaining board eligibility in their subspecialty.
• Identify an approved mentor or mentors with extensive research experience and extramural funding to help support the scholar’s research.
• Hold “New Investigator” status and not be or have been a PI on an R01, R29, U01/U10, subproject of a Program Project (P01), Center (P50, P60, U54) grant, or individual mentored or non-mentored career development award (e.g., K01, K02, K08, K22, K23, K24, K25, K99). Individuals who are or were PIs on NIH Small Grants (i.e., R03s) or Exploratory/Developmental Grants (i.e., R21s) may be eligible providing they meet the other eligibility requirements. Individuals who received Pediatric Scientist Development Program (PSDP) K12 funds are eligible for this program, subject to the 6-year limitation on mentored K support described below.
• Combined support through the K12 and other NICHD mentored career development award programs must not exceed six years.
• During the period of this award, Scholars may not accept or hold any other PHS award that duplicates the provisions of this career award. However, Scholars may compete for individual mentored career development awards (e.g., K01, K08, K23, K25, K99) provided they meet the eligibility requirements of those programs. Scholars may not hold concurrent K awards.
• Have written approval and support from their division chief for release from clinical time thus demonstrating capacity to spend 75% effort on the activities of this award.

The guidelines for the K12 Atlanta Pediatric Scholars Program grant application are:

1) Eligible Topics: Applicants may pose research questions and projects focused on laboratory-based, basic science projects in areas related to child health. See the “Research Topics Supported” section above and the "K12 Scholars" tab below for more details and relevant examples.

2) PI Effort: Applicants must dedicate 75% of their professional effort towards research activities associated with this award during the time of the award. 

3) Budget: 

• Total budget not to exceed $125,000 annually 
  • $100,000 allocated to salary and fringe to support the Scholar’s 75% dedicated research effort. Salary and fringe expenses that exceed $100,000 must be cost shared from internal funding sources.
  • $25,000 to support research expenses and career development activities of the Scholar.
• Must use the required budget template and contact Kim Caroline, Pre-Award Research Administration Director (kcaroli@emory.edu), for budget assistance at least three weeks before the submission deadline.

4) Duration: 

• Funding will be for a one year period with a possible extension to a second year. Extension to a second year is contingent on (1) the demonstration of satisfactory progress as assessed by the K12 Executive Committee, and (2) successful competitive renewal of the parent institutional grant.
• An annual progress report will be required 2 months prior to each budget year end date. 

5) Mentor(s): 

• Candidates must name a primary sponsor/mentor, who together with the candidate is responsible for the planning, direction, and execution of the program. 
• The mentor should be recognized as an accomplished investigator in the proposed area of research and have a track record of success in extramural funding and in training similar investigators. 
• There should be evidence that the mentor has an interest and commitment towards the scholar. Examples include but are not limited to shared space arrangements, previous monetary support & co-authored publications.
• A co-mentor and other collaborators can be named, but are not mandatory.

6) Plans for Extramural Funding: K12 Scholars are encouraged and expected to apply for independent research grant support during the period of K12 support (e.g., K08, R01). Funding goals should be outlined in the application including timing of and type of NIH or equivalent independent support that will be sought. This can either be a resubmission of a previously reviewed but unfunded application or a new application. 

7) Institutional Support: The division director or departmental chairman of each applicant for this K12 grant will be specifically involved in approving the K12 grant application, confirming 75% protected research time for the applicant and divisional cost share of any salary and fringe expenses that exceed the $100,000 provided by the grant, and ensuring that the extramural grant application is submitted as proposed in the K12 grant application. 

8) Deadlines:

• Required Letter of Intent (LOI): Submit via email to Stacy Heilman (stacy.heilman@emory.edu) by September 13 at 6:00 p.m. - Include your name, your mentor's name(s), project title, and a current CV or biosketch to ensure eligibility. While the LOI is not binding, it is required before submitting a full application.
• Full Application: Due October 4, 2024 at 6:00 p.m.

1) A Cover Page/Letter with the title of the application, the applicant’s name, department and division, address, and the name and application date of the extramural agency to which the extramural application will be submitted. This letter must be signed by the applicant, the applicant’s mentor(s) and the applicant’s division director indicating institutional support for the application and acceptance of the terms of the grant, including confirmation that 75% effort will be dedicated to research.

2) Biosketches (5 pages maximum each) – from the PI and mentor(s) following the current NIH format.

3) Other Support – Required from the proposed mentor(s). Please note, as described above, the mentor must have sufficient research funding in order for the application to be competitive for this program. More information on NIH's Other Support requirements are available here. 

4) Budget and Budget Justification

• Total budget not to exceed $125,000 annually
  • $100,000 allocated to salary and fringe to support the Scholar’s 75% dedicated research effort. Salary and fringe expenses that exceed $100,000 must be cost shared from internal funding sources.
  • ​$25,000 to support research expenses and career development activities of the Scholar.
• Must use the required budget template and contact Kim Caroline, Pre-Award Research Administration Director (kcaroli@emory.edu), for budget assistance at least three weeks before the submission deadline.

Other budgetary notes:

• Allowable research expenses from the $25,000 allotment may include:
  • Research expenses such as supplies, equipment and technical personnel, including expenses generated in the laboratories of the established investigators who serve as mentors
  • Travel to attend the annual Scholars meeting
  • Travel to receive training or attend scientific meetings
  • Tuition, fees, or books
  • Technical support for data analysis and statistical or computer services
  • Items that may NOT be supported within the $25,000 support category include: mentor salary support; direct support of the laboratories, travel, and research projects of the investigators serving as mentors beyond those expenses directly attributable to the scholar's project
• The budget justification should state that the proposed mentor has sufficient independent support to cover the costs of the proposed project in excess of the allowable budget of this award.
• Proposals do not need to be routed for institutional signoff, but candidates should work with their RAS Pre-Award contacts for assistance in creating the budget.

5) Other Supporting Documentation:

• Project Abstract (limit 1 page)
• Project Narrative (2-3 sentences)
• Institutional Environment Section (limit 1 page)

6) Specific Aims of the Proposed Research (limit 1 page)

​7) Candidate Information Section describing the candidate’s background, career goals and objectives, career development/training activities during the award period and the training in responsible conduct in research. (recommend 4 pages maximum)*

8) Research Strategy including Significance, Innovation and Approach of the proposed research (recommend 8 pages maximum) including preliminary data. References should be included at the end of this section, but are not included in the page limit.*

*NOTE: The Candidate Information Section and the Research Strategy section together must not exceed 12 pages (white space at the end of each section is not counted). If the text exceeds 12 pages for these two sections, your application will be returned without review.

9) Statement(s) by the Mentor/Co-Mentor and any other key contributors important to the scholar's research career success. (limit 6 pages)

10) Vertebrate Animals Section (if applicable) - The Vertebrate Animals Section is a standalone document and must include enough procedural details for evaluation even if these details are included elsewhere in the grant application, publications, IACUC protocol, or institutional SOPs/guidelines. The details should include:

• A general experimental timeline for animals from start until euthanasia.
• For ALL procedures on a live animal: frequency and duration of procedures, identification of and routes of administration of substances, experimental endpoints, and monitoring parameters and monitoring frequency.
• Examples of the types of procedures that may be described include:
  • Behavioral tests
  • Blood collection
  • Surgical procedures
  • Administration of substances
  • Tumor induction
  • Post-irradiation procedures

11) Response to Prior Reviews - If the research project has previously been submitted for consideration to an institutional K mechanism (including this K12 opportunity) or for extramural funding, the applicant should include a copy of the critique from the prior submission and within a 1 page limit, indicate how the criticisms will be addressed by the new work funded by this K12 grant submission.

12) Letters of Suport - Letters of support can be used to reinforce attributes of the proposed work, team of investigators, mentorship and institutional resources/leadership. They can also be used to highlight a contribution of a research resource or material that is unique and/or essential to the successful completion of the proposed research. Letters of support are not required.

13) Submission must be completed by the deadlines stated in this Request for Applications. 

These sections are to be fashioned after the NIH K application requirements and must adhere to all formatting requirements. Detailed instructions can be found within the SF 424 application guide under the supplemental instructions for CDA’s found at this link: https://grants.nih.gov/grants/how-to-apply-application-guide/forms-e/career-forms-e.pdf 

You must apply through our Grants Management System, InfoReady Review, here.

Programmatic & Eligibility Questions:

Ann Chahroudi, MD, PhD
Training Director

Jason Yustein, MD, PhD
Recruitment Officer

Stacy Heilman, PhD
Operations Director

Why is this program limited to pediatric faculty embarking on basic science careers? Why are clinical researchers not supported by this program?

The NICHD-funded Child Health Research Career Development (K12) Awards are specifically designed to prepare pediatricians for careers in basic science investigation relevant to childhood illnesses. While clinical research careers are equally valued by our leadership and institutions, this particular K12 program is not designed to support clinical research careers. Below are specific citations from the RFA that provide evidence of this focus:

Stated Purpose
The National Institute of Child Health and Human Development (NICHD) supports a program of Child Health Research Career Development Awards (CHRCDA) intended to develop resources to speed the transfer of knowledge gained through studies in basic science to clinical applications that will benefit the health of children. The CHRCDA supports research career development of pediatricians who have recently completed subspecialty training and who are commencing basic research training relevant to child health. The goal of this initiative is to advance research in child health and to support educational institutions in their ability to stimulate novel research initiatives and career development experiences for junior investigators. This is accomplished by increasing the number and effectiveness of established pediatric investigators who have a grounding in basic science and research skills that can be applied to the health problems of children, as well as by increasing the number of pediatric medical centers that can stimulate and facilitate the application of research findings to pressing pediatric problems.

APSP Specific Aims: The Specific Aims of the Atlanta Pediatric Scholars Program at Emory University include:

Aim 1. To attract outstanding physician-scientist candidates to the pursuit of basic science research careers in areas relevant to child health.
Aim 2. To prepare physician-scientists for independent careers in child health research through a dynamic career development program involving mentored laboratory research experience, didactic course work, career skills training, and academic participation. This program includes opportunities to work and collaborate with investigators at Emory, Children’s Healthcare of Atlanta, and Georgia Tech.
Aim 3. To monitor the progress of the CHRCDA trainees and assess the overall success of the program through rigorous internal and external review processes. The program will include mechanisms to respond to ongoing reviews in ways that will facilitate programmatic goals.

What other career development opportunities are available to pediatrician physician scientists at Emory University?
 The APSP K12 focuses exclusively on training pediatric scientists engaged in basic research. This complements yet does not overlap with the existing Georgia CTSA KL2 Scholars Program, whose focus is expressly on clinical and translational career development for MD clinician scientists and PhD translational scientists and is available for all disciplines, pediatric or adult, across multiple partner institutions. Although separate programs, the APSP successfully leverages the Georgia CTSA career development infrastructure and didactic course offerings such as MSCR 594M - Scientific and Grant Writing, and MSCR 761M - Introduction to Clinical and Translational Research. The K-Club and internal pilot awards programs provide additional career development options for all junior health scientists at Emory.

How is the success of the APSP judged?

It is critical that we recruit new faculty into the Atlanta Pediatric Scholars Program who are pursuing basic science careers and who will be very productive during and after training. The program is judged by the success of its scholars, including by the quality and quantity of their publications and especially by their ability to obtain independent NIH grants. The reviewers for our renewal application will assess specific criteria outlined in the goals of the program. The best scenario is that we will be able to show a number of trainees who have become R01 (potentially K08) funded in their area of research and who are producing high quality publications that demonstrate high productivity and independence.