Skip to Content

Center for Gastroenterology, Endocrinology, & Nutrition Innovation (GENI)

The Center for Gastroenterology, Endocrinology, and Nutrition Innovation (GENI) aims to address the causes and consequences of the growing epidemic of childhood obesity, and associated comorbidities, including cardiometabolic diseases, diabetes, and steatotic liver diseases, through research into contributions from genetic, environmental, nutritional, and lifestyle factors.

The effects of obesity on child health are widespread since metabolic impairments associated with obesity also contribute to outcomes and response to therapies for a variety of childhood disorders. A major concern is that overweight beginning in childhood can promote later development of serious liver disorders, cardiovascular disease, diabetes, and early-onset cancers in a large portion of society. Unchecked, the epidemic of childhood obesity could overwhelm an already overburdened health care system and exacerbate existing health inequities. In addition to childhood obesity, GENI also serves as a home for nutritional, endocrine, GI/liver, and metabolic research. Actionable goals for GENI include: identification of children at greatest metabolic risk; development of new diagnostic and treatment approaches; and the education of patients, colleagues, and caregivers. Taken together, we anticipate practical and effective ways to change the life trajectories of these children towards a healthy and fulfilling future.

Our current research goals include:

  • Stratify future risk in diverse longitudinal clinical cohorts of well and diseased children with a focus on metabolic wellness
  • Multi-omics and clinical phenotyping as a basis of risk stratification by discovering genetic, social, diet, microbial, or host-derived serum biomarkers of future disease
  • Incorporation of guidance from an adult specialist for early identification of preventable adult diseases
  • Develop guidance for transition of adolescent patients with metabolic, endocrine, or congenital liver and GI disorders to adult healthcare
  • Pre-clinical disease modeling and therapeutic testing
  • Therapeutic target discovery and molecular interventions

Our prioritized research areas:

GENI's research areas
GENI's Research Areas

 

Pediatric Research Grand Rounds:

Pediatric Steatotic Liver Disease: The Future is Bright

Marialena Mouzaki, MD, MSc
Medical Director, Advanced Nutrition Therapy Services
Associate Director, Steatohepatitis Center
Program Director, Advanced Nutrition Fellowship
Cincinnati Children's Hospital Medical Center
Professor, Department of Pediatrics
University of Cincinnati

Wednesday, March 19, 2025  8:00 - 9:00am 

Recordings of recent seminars:

Click here to be added to the GENI email list to stay up-to-date on the latest news and upcoming events.

Click here to express interest in GENI center membership. Read more about pediatric research center membership here.

Meet the Team


Upcoming Events

Mon May 51:00PM-2:00PM
CCIV Seminar- Erin Scherer, PhD
Mon May 121:00PM-2:00PM
CCIV Seminar- Devyani Joshi
Thu May 1510:00AM-4:00PM
Inaugural REACH Retreat
Mon May 191:00PM-2:00PM
CCIV Seminar- Ashish Sharma
Wed May 2112:30PM-1:30PM
HeRO Rapid Fire Seminar Serie
Thu May 224:00PM-6:30PM
Fellow Research Day
Mon Jun 21:00PM-2:00PM
CCIV Seminar- Cheryl Day
Mon Jun 91:00PM-2:00PM
CCIV Seminar- Meenakshi Kar
Mon Jun 161:00PM-2:00PM
CCIV Seminar- Mojahidul Islam

Join the Pedsresearch Listserv

Back to top