Faculty Directory
Daniel S. Wechsler, MD, PhD
Pediatric Hematologist/Oncologist,
Section Director of Oncology,
Co-Director of Peds Hem/Onc Fellowship Program,
Thomas R. Giddens Chair,
Aflac Cancer & Blood Disorders Center
Children’s Healthcare of Atlanta
Professor of Pediatrics,
Emory University School of Medicine
Ertha Sinclair
Administrative Assistant
Aflac Cancer and Blood Disorders Center
ertha.sinclai@emory.edu
404.727.5873
EMAIL: .(JavaScript must be enabled to view this email address)
Biography
Our research focuses on the pathogenesis of infant leukemias. We have shown that the nuclear export chaperone CRM1 plays a direct role in CALM-AF10 leukemogenesis by activating HOXA gene expression. CRM1 appears to be similarly involved in other leukemias, suggesting that available CRM1 inhibitors may be effective anti-leukemic therapeutic agents.
Research
Molecular Biology of Neuroblastoma
Regulation of Transcription of MYC family proteins
Role of Endocytosis in Pathogenesis of Acute Myeloid Leukemia
Pathogenesis of MLL-dependent Acute Leukemia
Nuclear Export Signals in Leukemogenesis