Peter Martin Thule, MD
Adjunct Clinical Associate Professor, Morehouse School of Medicine
Professor of Medicine, Emory University School of Medicine
Research Development of insulin gene therapy as a treatment for diabetes mellitus, and investigations into hepatocellular effects of ectopic insulin production. Our animal model utilizes a metabolically regulated, hepatic specific gene promoter to drive expression of an insulin transgene in the livers of diabetic rats. Administration of viral vectors containing these promoters coupled to a human insulin cDNA, normalizes blood sugars in diabetic rodents.