RFP Announcement - 12/01/2023
Letter of Intent Due – 01/19/2024
Application Released - 01/29/2024
Application Due - 3/29/2024
Notification of Winners - June 2024

PI: Kelly Goldsmith, MD

Co-PI: Trent Spencer, PhD

Project Title: A Phase I Study of Allogeneic Ex Vivo Expanded Gamma Delta (γδ) T Cells in Combination with Dinutuximab, Temozolomide, and Zoledronate in Children with Refractory or Relapsed Neuroblastoma

PI: Tobey MacDonald, MD

Co-PI: Kavita Dhodapkar, MD

Project Title: AflacST1901 A Phase I Study of WP1066 in Children with Refractory and Progressive or Recurrent Malignant Brain Tumors

PI: Melinda Pauly, MD

Co-PI(s): Thomas Alexander, MD, MPH (UNC), William G. Blum, MD (Emory), Joshua Zeidner, MD (UNC)

Project Title: An Open-Label Evaluation Phase 1 Trial of the Safety and Pharmacokinetics of MRX-2843 in Adolescents and Adults with Relapsed/Refractory Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, or Mixed Phenotype Acute Leukemia

PI: Kathryn Sutton, MD

Co-PI: W. Thomas Cash, MD, MSc

Project Title: A Maintenance Protocol of Sirolimus in Combination with Metronomic Chemotherapy in Children with High-Risk Solid Tumors

PI: Kirsten Williams, MD

Co-PI: Muna Qayed, MD, MSc

Project Title: CD19/22 CARPOOL: Phase I trial of CD19/22 Chimeric Antigen Receptor Protocol with Objective of Tolerability in relapsed/refractory B-ALL

PI: Bree Eaton, MD

Co-PI(s): Hyunsuk Shim, PhD (Winship) and Claire Mazaewski, MD (Aflac Cancer Center)

Project Title: Spectroscopic MRI for the management of pediatric high-grade glioma patients

PI: Edwin Horwitz, MD, PhD

Co-PI(s): Muna Qayed, MD, MSc

Project Title: Interferon γ-Primed Mesenchymal Stromal Cells as Prophylaxis for Acute Graft v Host Disease after Allogeneic Hematopoietic Cell Transplantation for Patients with Hematologic Malignancies and Myelodysplasia

PI: Robert Craig Castellino, MD

Co-PI(s): Tobey MacDonald, MD

Project Title: First-in-Child Phase I Trial of MinnelideTM in Malignant Pediatric Brain Tumors

PI: Tobey MacDonald, MD

Co-PI(s): Robert Craig Castellino, MD

Project Title: Repurposing Atovaquone for the Treatment of Pediatric Malignant Brain Tumors

PI: Dolly Aguilera, MD

Co-PI(s): Claire Mazewski, MD, Tobey MacDonald, MD, Robert Craig Castellino, MD, Kavita Dhodapkar, MD

Project Title: Phase II, Prospective Trial of Poly-ICLC (Hiltonol) Treatment in Children and Young Adults With Progressive Low-Grace Gliomas

PI: Muna Qayed, MD, MSCR

Co-Pi(s): Nirali Shah, MD, MHSc (National Cancer Institute), Marie Bleakley, MD, PhD (Fred Hutchinson Cancer Research Center),

Project Title: CAR T-cells for Long-TermCure: A Risk-Based Approach to Post CD19 CAR T-cell Consolidation with Hematopoietic Stem Cell Transplantation for Pediatric, Adolescents and Young Adult B-cell Acute Lymphoblastic Leukemia

PI: W. Thomas Cash, MD, MSc

Co-PI(s): Lara Davis, MD (Oregon Health & Science University), J. Andrew Livingstone, MD (UT MD Anderson Cancer Center), Bree Eaton, MD, Megan Durham, MD (Emory University/Children’s)

Project Title: Pilot Study of atezolizumab in combination with stereotactic body radiation therapy (SBRT) and surgery in pediatric and AYA patients with pulmonary recurrence of osteosarcoma

PI: Sunil Raikar, MD

Co-PI(s): Kirsten Williams, MD, H. Trent Spencer, PhD

Project Title: Third-party allogeneic gamma delta T-cells for relapsed/refractory acute myeloid leukemia and T-cell acute lymphoblastic leukemia

PI: W. Thomas Cash, MD, MSc

Co-PI(s): Jason Yustein, MD, PhD

Project Title: A Phase 1b Study of Tegavivint, a TBL1 inhibitor, with Gemcitabine in Children, Adolescents, and Young Adults with Relapsed or Refractory Osteosarcoma