Pricing
(See individual model strains below - prices last reviewed 9/18/2026)
Price adjustments will be made as needed to ensure proper care and quality as per DAR cost adjustments. Prices are the minimum cost to provide the following services:
- Assistance in ordering and planning the breeding schedule
- Breeding colony maintenance
- Breeding set up and housing until the mice are handed over to your protocol by DAR staff
- Genotyping through Transnetyx for 2 alleles
- Delivery of mice to DAR Facility of choice
An order will consist of a minimum of 32 mice including 8 KO/mutant, 8 WT, and 16 hets. In order to ensure this minimum delivery based on an 8-pup litter we will always breed an extra pair that will be genotyped and included in the cost, and any extra mice from the breeding setup will be yours.
Contact Dr. Dina Moustafa if you have further questions.
Actively-Maintained/Bred Murine Strains
Scnn1b-Transgenic (β-ENaC)
Price per mice litter order: $2,531
Strain: B6;C3H-Tg(Scgb1a1-Scnn1b)6608Bouc/J
These Scnn1b-transgenic mice overexpress the mouse epithelial sodium channel beta subunit (Scnn1b) under the control of the rat secretoglobin family 1A member 1 (Scgb1a1, also known as Clara cell secretory protein) promoter. This model develops airway disease characterized by: Airway mucus obstruction, Neutrophilic inflammation, Goblet cell metaplasia, Mucus hypersecretion.
These features closely resemble the clinical and pathological manifestations of early cystic fibrosis lung disease. Scnn1b-transgenic mice are available on a C57BL/6J background.
For additional information about this strain, please visit the Jax website.
Humanized F508del CFTR (HDFT)
Price per mice litter order: Contact us for pricing details
Strain: B6.Cftrem2CwruTg(CFTRF508del)1Lcl/Cwr
These mice have the clinically relevant F508del mutation created using endonuclease mediated gene editing in the mice as described by Gawenis et al. (2019). The strain expresses human CFTR harboring the clinically relevant F508del mutation with mouse null. This humanized CF mouse model carries a bacterial artificial chromosome (BAC) transgene containing the human CFTR gene and its regulatory elements making them a valuable model for studying CFTR-directed therapies and disease mechanisms.
Strains Available Upon Request
Gut-Corrected CFTR Knockout
Price per mice litter order: $888
Strain: Cftrtm1UncTg(FABPCFTR)1Jaw/J
These mice carry a complete Cftr knockout while expressing a human CFTR transgene specifically within the intestinal epithelium. Expression of the human CFTR transgene is driven by the fatty acid binding protein-1 (FABP1) promoter. The restoration of CFTR function in the intestinal epithelium, with little to no transgene expression in the lung, improved survival compared with conventional CFTR knockout mice, and elimination of the need for liquid diet intervention.
Mice homozygous for both the Cftr knockout allele and the FABP-hCFTR transgene demonstrate significantly improved longevity, making this model useful for investigating extra-intestinal manifestations of CF.
Additional information is available through the Jax website.
Delta F508 (a.k.a ΔF or ΔF508) **Frozen Stock Only**
*Due to the high incidence of mortality, this strain is only available as frozen stock*
Price per mice litter order: Contact us for pricing details
Strain: B6.129S6-Cftrtm1Kth/J
The Cftrtm1Kth mutation corresponds to the F508del mutation, the most common disease-causing mutation found in individuals with cystic fibrosis.
Characteristics of this model include: Increased mortality during the first month of life due to Intestinal complications (including bowel obstruction, bowel strictures, and peritonitis), reduced body size compared with wild-type littermates, fertility in surviving animals, although females are poor breeders. The model also exhibits tissue-specific loss of CFTR transcripts in the intestine.
Despite its limitations, the ΔF508 mouse remains one of the most widely used murine models of cystic fibrosis.
Additional information is available through the Jax website
Future Model Development
The CF Animal Models Core is committed to supporting the evolving needs of the cystic fibrosis research community. We welcome suggestions for additional CF mouse models that may benefit investigators and advance CF research.
For inquiries or recommendations regarding new CF mouse models, please contact Dr. Nael McCarty.
Meet the Team
