$190 - Discovery Metabolomics:  LC-MS of all detectible metabolites, annotated using in-house library of hundreds of metabolite standards (609 entries registered as of May 1, 2025) and online databases of thousands of reference MS/MS spectra. Important unknown metabolites can be detected and identified with follow-up analysis and experiments. Available now.

$167 - Polytargeted Metabolomics:  

Massively targeted metabolite analysis using AI data processing, polarity switching, and triple quadrupole technology for faster throughput and higher sensitivity than discovery metabolomics. Ideal for large studies, dilute/low concentration specimens, and projects prioritizing accelerated turnaround times. Available now.

$167 - Isotope Tracing & Fluxomics*:  Tracing stable isotopes across metabolic reactions in live cells and organisms or isolated biochemical systems. This is the gold standard to determine which metabolic pathways are active and to discover new ones. The distribution of metabolite isotopologues (labeling patterns) within specific metabolites is reported along with overall isotopologue abundances. Available now.

*Note: For fluxomics experiments, we require at least one sample that did not receive isotopically labeled nutrient(s)- this is called the Unlabeled Control. Typically you would use the same nutrient source at the same concentration but not isotopically labeled, e.g. normal glucose instead of U-13C-glucose. Please provide one Unlabeled Control per experimental group in your study. The purpose of the Unlabeled Control is to establish natural isotopic patterns for all detected metabolites, and it is not used for quantitative comparisons. This means it is fine if the Unlabeled Control is not processed at the same time as other samples, though it may still be ideal to synchronize experimental conditions as much as possible. Also, please provide a sample of isotopically labeled sterile media that was not exposed to cells. This is used to confirm isotopic purity.

$125 - Targeted Quantification:  Panels of small molecules assayed by LC-MS using triple quadrupole MS, with isotope dilution calibration to molarity. This is the gold standard for rigorous metabolite quantification. Current offerings are listed below. Custom assays are available on request. Available now.

List of current offerings:

• Amino acids and biogenic amines
• Arginine metabolism
• Carbohydrates (mono- and disaccharides)
• Citric acid cycle
• Drugs and xenobiotics (e.g., CFTR modulators; nicotine)
• Glutathione and cysteine redox
• Glycolysis
• Oxidative stress biomarkers
• Pentose phosphate pathway
• Protease biomarkers
• Purines and pyrimidines
• Ribo- and deoxyribonucleotides

$312 - Metabolomic Imaging:  MS imaging of tissue and other 2D specimens ionized by laser desorption. Gold standard for determining the localization of metabolites in tissue. Expected release date: Q2 2026

$60/hour